Kidney Stones and Magnesium

Kidney Stones and Magnesium

Kidney stones develop when the compounds in the urine accumulate in a solid mass. They can lead to urinary blockage and severe pain. There are variou

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Kidney stones develop when the compounds in the urine accumulate in a solid mass. They can lead to urinary blockage and severe pain. There are various kinds of stones, with some of the most usual being uric acid stones, calcium phosphate, and calcium oxalate. The generation of kidney stones is twice the chance of getting chronic kidney illness and reduce kidney function.

Calcium, vitamin B6, and magnesium, and probiotics can help to stop kidney stones.

How Kidney Stones Form

Urine was more focused when it runs on the kidneys and the water is reabsorbed in the bloodstream (Sands 2009). Organic molecules and minerals are melted in the urine can crystallize if the urine was intense. These crystals can be attached together and generate difficulty with other molecules, especially on the proteins. These crystalline-protein groups are the primary of kidney stones. (Aggarwal  2013; UMMC 2014).

Here are the five major kinds of kidney stones (Aliotta 2015; Preminger 2015; Antonelli 2015):

Calcium oxalate – 60-80% of all kidney stones are predominantly calcium oxalate or completely calcium oxalate with a tiny percentage of calcium phosphate.

Calcium phosphate – Purified calcium phosphate stones are less frequent which accounts around 10-20% of all kidney stones.

Uric acid – 20% of all kidney stones are account in uric acid stones.

Struvite – Kidney stones are formed of struvite which is magnesium ammonium phosphate that has 1-7% of problems. Struvite stones are connected with chronic urinary tract infections that include particular kinds of bacteria and are higher than 3 times common to occur in women.

Cystine – Stones that formed of the amino acid cysteine are more common to occur in children and uncommon for adults which express 1-3% of all kidney stone problems.

Dietary Risk Factors

High salt intake

A high-salt intake can add to the danger of kidney stone because consuming high sodium can increase urine calcium concentration (Sakhaee, Maalouf 2012; Friedlander 2015).

High sugar intake

A high-sugar intake can increase the danger of kidney stones which can link to the ability of big amounts of carbohydrates and refined sugar to soothe urine calcium (Thom 1978; Garg 1990). In a 12-year research of around 91731 women, those women who consume most refined sugar were 52% growth kidney stones than those women who consume a little bit (Curhan 1997). In the research, almost 200,000 on the average of eight years, those individuals who eat the most sugar-sweetened soft drinks have 23% of the risk to form kidney stones, unlike to those who consume a little bit (Ferraro 2013).

Low calcium intake

Proof from several large observational research and a randomized controlled trial has revealed that limiting the intake of calcium doesn’t stop stone formation even though the dietary limit of calcium was believed to lessen the calcium-containing stone risk and urine calcium (Friedlander 2015). Calcium really connects to oxalate the digestive tract which stops the oxalate to invade the bloodstream. This can help to lessen urinary oxalate and help to stop calcium to oxalate kidney stones. This thought was getting support from the epidemiologic research that has revealed that lessening the consumption of dietary calcium can raise the risk of kidney stones (Sakhaee, Maalouf 2012; Sorensen, Eisner 2012).

Low fruit and vegetable intake

Many vegetables and fruits give alkaline-forming substances that include potassium, citrate, and bicarbonate which can help to increase urinary citrate, alkalinize the urine, lessening the risk of kidney stone, and decrease urinary calcium excretion (Morris 1999).

Conditions Associated with Increased Kidney Stone Risk

Impaired kidney function

Kidney disorders and illness that reduce renal calcium handling can leads to raises the danger of kidney stones and high urinary calcium. Kidney illnesses can lead to raises of the urine which also add to the risk of the kidney stone (Arrabal-Polo, Arrabal-Martin 2013; Aliotta 2015).

Hyperparathyroidism

Parathyroid hormone levels are raised. This can cause increased blood calcium levels, raising intestinal calcium absorption, urine calcium concentrations, calcium extraction from bones, and danger of kidney stone (Gasser 2013; Nussey 2001; Moe 2008).

Osteoporosis

Developing proof recommends that strong ties between kidney stones and bone loss. This can result in some researchers to suggested an osteoporosis testing for those people that have generated chronic kidney stone (Arrabal-Polo, Sierra Giron-Prieto 2013).

Digestive and intestinal disorders

Those people with inflammatory bowel illnesses or chronic diarrhea like Crohn’s illness and ulcerative colitis can receive more dietary oxalate which caused to the raised of the danger of calcium oxalate stone and hyperoxaluria (Aliotta 2015). Hyperoxaluria can happen to those people with fat malabsorption because of the digestive disorders or after gastrointestinal surgery which involves bariatric surgery for weight loss. The remaining unabsorbed fat in the gut connected to calcium which can’t be connected to and hinder the absorption of oxalate (Arrabal-Polo, Arrabal-Martin 2013; Nazzal 2015).

Type 2 diabetes

Those people with diabetes were much higher urinary uric acid and more acidic urine and oxalate, unlike the people without diabetes. This can lead to raised the danger of calcium oxalate kidney stones and uric acid (Eisner 2010; Torricelli 2014; Hartman 2015).

Kidney stones, insulin resistance, and metabolic syndrome

The American Heart Association describe metabolic syndrome through the appearance of three or higher of the risk factors which are high triglycerides, abdominal obesity, raised fasting glucose, low HDL cholesterol, and high blood pressure. Metabolic syndrome was connected with the raised of the danger of kidney stones (Sakhaee 2008; Wong 2015; Kaur 2014; AHA 2014).

Integrative Interventions

Magnesium

Magnesium can affects calcium oxalate stone which can produce the danger by several mechanisms. Magnesium treats oxalate in the digestive tract and hinders the generation of calcium oxalate crystals in the urine (Kohri 1988; Massey 2005). Taking a significant amount of magnesium was connected to lessen the danger of kidney stones (Negri 2013; Zimmermann 2005).

Those consuming highest 1/5 of magnesium had a 29% lower risk of generating kidney stones based on research over 45,000 US male health professionals (Taylor 2004). Another research in 311 patients that have kidney stone illness estimated magnesium levels in urine which is a known marker of consuming dietary of magnesium. Significant of urine magnesium was associated with lessen urine oxalate (Eisner 2012).

Taking a magnesium supplement was crucial in the circumstances of kidney stones. Magnesium was present in the digestive tract as oxalate-containing foods to stop it from being absorbed in general circulation and treat dietary oxalate wherein the oxalate needed to be cleaned by the kidneys and is passed on the urine. Researchers noted administration of a magnesium supplement along with oxalate can help to reduce oxalate absorption in clinical research of six healthy volunteers were taking magnesium supplement 12 hours far from the oxalate administration didn’t have this effect (Zimmermann 2005).

Calcium

A low-calcium diet is connected to a higher chance for calcium oxalate stones (Xu 2013). Meanwhile, the high dietary calcium was followed by a big increase of oxalate intake which was shown to reduce the risk of kidney stones instead of raising it (Hess 1998; Sorensen, Kahn 2012; Taylor 2004). This is believed to be because of the ability of calcium to connect dietary in the intestines which stops oxalate absorption to the bloodstream, and urine and kidney (Nazzal 2015). Taking enough calcium on supplementation and diet is connected with higher bone mineral density (Napoli 2007). This might be another method of consuming enough calcium to stops kidney stones. The content of urinary calcium and raise the risk of stone once the bone mineral density reduces (Arrabal-Polo, Sierra Giron-Prieto 2013). Bone resorption or also known as the breakdown of the bone can lead to the calcium to leach in the blood and in the urine which raises the damage of stone. Consuming enough calcium can give security on the kidney stones and decreases bone resorption (Ettinger 2014; Heaney 2008; Martini 2002).

In the research around 45,000 male health professional without having kidney stones were followed for more than 14 years, those men who age range of 60 were in the largest one-fifth of dietary intake of calcium which had a 31% lessen the danger of kidney stones, unlike one-fifth who take the least calcium (Taylor 2004). Another research conducted in around 78,000 women without kidney illness shown that having a lot of dietary calcium was connected with a 5-28% decreased in the danger of kidney stones and a research around 96,000 young women without kidney stones shown that those in the highest one-fifth of taking dietary calcium had a 27% lessen the chance of kidney stones unlike to those women who have the lowest one-fifth (Sorensen, Kahn 2012; Curhan 2004).

Calcium supplements can help to decrease the risk of kidney stones and enhance urine chemistry parameters even to those who have a low-oxalate diet. Research in 32 healthy young men without any history of kidney stones shown that calcium supplementation, mixed with lowered urine oxalate, low-oxalate diet (Stitchantrakul 2004).

Calcium supplements needed to be consumed with meals to get the maximal amount of dietary oxalate (Domrongkitchaiporn 2004; Heilberg 2013).

Mineral Citrates

The most usual varieties of kidney uric acid, calcium oxalate, and kidney stones lead to the creation of acidic urine. The generation of the unusual cystine stones, kidney stones also happens in acidic urine (Frassetto 2011). Citrate helps to protect these kinds of stones by restraining calcium oxalate crystallization, getting calcium in the urine and in the gut, and alkalinizing the urine Goldberg 1989; Nicar 1987; Krieger 2015; Berg 1992). Mineral citrates which include potassium, magnesium, and calcium are used in research and clinical practice to decrease the rate of stone generation, alkalinize the urine, and enhance urinary citrate (Caudarella 2009; del Valle 2013; Sakhaee 2004; Ettinger 1997).

The citrate and magnesium can hinder calcium oxalate crystal generation by mixing the two were more efficient (Rodgers 1999).

In the trial in 64 people with a calcium oxalate kidney stones history, three years of potassium-magnesium citrate supplementation gives around 255 mg of magnesium which leads to an 85% decreased in the danger of kidney stones, unlike with placebo (Ettinger 1997). Potassium-magnesium citrate supplementation has efficiently alkalinized the urine which decreases calcium oxalate crystallization potential, efficiently alkalinized in the urine, decrease uric acid concentration in the urine, and raise citrate concentration in the double-blind placebo-controlled trial in around 20 participants who undergo to bed rest for around five weeks (Zerwekh 2007).

Research use in various different mineral preparation of magnesium and potassium revealed that using potassium-magnesium citrate or including a magnesium supplement to potassium citrate therapy can lead to enhance urine chemistry, unlike to remedy without having magnesium (Jaipakdee 2004; Kato 2004).

Potassium citrate was used to hinder calcium phosphate crystals and calcium phosphate crystals, alkalinize the urine, decrease the kidney stones risk, improve urine citrate (Arrabal-Polo, Arrabal-Martin 2013; Xu 2013; Sakhaee, Griffith 2012).

The potassium citrate was used to stop kidney stones is around 1200–2400 mg every day which is a prescription-strength dose that usually makes painful for some people and leads to the digestive problem (Xu 2013). Potassium citrate dietary supplements often didn’t contain up to 99 mg of potassium every pill it is a less concentrated source of urine-alkalinizing citrate compared to calcium or magnesium forms of citrate (Higdon 2010).

The research used a supplement that possesses potassium citrate and calcium citrate enhance urine chemistry by raising urinary citrate and decreasing acidity to those people who undergoes with gastric bypass surgery (Sakhaee, Griffith 2012).

Probiotics

The gastrointestinal tract’s bacterial populations have a major role in breakdown metabolism and oxalate which can stop kidney stones (Miller 2013; Murphy 2009).

Different general probiotic bacteria that includes Bifidobacteria and Lactobacillus can reduce the danger of kidney stone, decrease urinary oxalate, and has the ability to metabolizing oxalate. Six people that have high urinary oxalate concentrations and calcium oxalate kidney stone disease take a supplement that has Bifidobacterium and Lactobacillus filters in around 4 weeks (Campieri 2001). Meanwhile 10 patients with extreme intestinal oxalate absorption which can result in many different medical problems, the patients were given a probiotic formula that has Bifidobacterium and Lactobacillus strains. The average of urine oxalate was around 19% by about 24% at a dosage of two every day (Lieske 2005). But the trials that used the similar probiotic formulation can give a similar beneficial effect of it (Lieske 2010; Goldfarb 2007).

The 11 healthy people were given by the probiotic supplement that contains different Lactobacillus and Bifidobacterium. The oxalate absorption was decreased after 4 weeks of taking probiotic supplementation which can affect to the sealed decreased of the individuals who received high oxalate absorbers at the start of the research (Okombo 2010). Another research that consists of 14 people without hyperoxaluria was given a probiotic supplement thrice a day after means for around 2 weeks together with a high-oxalate diet. Half of the research encountered a decrease of urinary oxalate which is the large decrease in two people who had the largest raises on urinary oxalate on the high-oxalate diet (Ferraz 2009). Laboratory research has several bacterial strains that can be seen in Lactobacillus species that showed a larger oxalate-degrading ability, unlike Bifidobacteria (Mogna 2014).

Vitamin B6

Lack of vitamin B6 affects around 24% of US adults and might in included to be hindered by a high-protein diet. Lack of vitamin B6 will raise the risk of kidney stone and urine oxalate in laboratory humans and animals, and hyperoxaluria that was completely decreased with the supplementation of vitamin B6 (Murthy 1982; Nath 1990; Kim 2014; Mitwalli 1988; Massey 2003). In 14-year research around 85,557 women danger of kidney stone was lower around 34% in women who take vitamin B6 every day from the supplements and diet, unlike those who will take the least (Curhan 1999). In another research, 149 people with chronic kidney stones were cured with 100 mg thrice a day every day of magnesium oxide, which includes 10 mg once every of vitamin B6 for around 4.5-6 years. The chronic rate falls downs in 1.3 every year to 0.1 every year on the treatment which a 92% decrease (Prien 1974).

Fish Oil

Some research revealed that the omega-3 fatty acids eicosapentaenoic acid (EPA) supplementation and docosahexaenoic acid (DHA) from the fish oil might decrease the danger of kidney stone by lessening urine calcium. People with a history of kidney stones were cured with a small course for three months and a long course around 18 months of around 1800 mg EPA every day in one research. The concentrations of urine calcium fall to those people who joined in the research with normal urinary calcium (Yasui 2001). 15 healthy people received 600 mg DHA and 900 mg EPA every day for around 30 days that has extreme calcium oxalate saturation and urinary oxalate excretion was reduced on the end o the trial (Siener 2011).

N-Acetylcysteine

N-acetylcysteine (NAC) was used by cells to detoxify free radicals and provides glutathione (Zhang 2011; Rushworth 2014). A research with separate clinical, preclinical, and laboratory properties discovered the tree lines of proof that revealed the potatenial of NAC to stop the generation of kidney stones and calcium oxalate crystals. 17 people who have calcium oxalate kidney stones were cured with 3 g every day of NAC in the clinical aspect of this trial. The number of large urinary calcium oxalate crystals was decreased by around 60%, and there are three people who already encountered a natural exit of stones after one week of treatment (Fan 1994). The discovered after animal and laboratory research that gives extra proof that NAC may guard the kidney cells against the harmful effects of calcium oxalate and decrease calcium oxalate crystallization (Bijarnia 2008; Fishman 2013; Davalos 2010). NACH also shown activity that can help to guard on the type 2 diabetes by several mechanisms and enhance insulin sensitivity (Lasram 2015). NAC guarantees an integrative strategy for the blocking of kidney stones since the insulin resistance seems to be connected to the damage of kidney stone (Assimos 2004; Wong 2015).

Vitamin E

Vitamin E can help to guard the lipid molecules in cells and in the blood from stress and oxidative damage (Princen 1995; Ni 2012). Vitamin E was protecting the animal kidney cells from oxidative damage because of the high oxalate problems, which recommends a major role in stopping stone beginning and crystal deposition in laboratory research. It can be observed that the protective effect of vitamin E was to improve the increase of antioxidant vitamin C (Thamilselyan 2014). Animal research discovered that vitamin E hinders the beginning of stone by guarding the oxidative injury in kidney cells, hinders crystal deposition in kidney tubule cells, and decrease calcium oxalate crystallization (Huang 2006; Thamilselvan 2005).

Green Tea and Catechins

Green tea and green tea extracts were plenty in phytochemicals known as catechins which can hinder the generation of calcium oxalate stone (Jeong 2006; Itoh 2005; Graham 1992). The epicatechin and flavonoids catechin were assessed for their ability to modulate the biochemical danger factors of kidney stone in animal research. Those who get epicatechin or catechin can have less crystals withdraws in the kidneys ad lessen kidney calcium, unlike with rats that receiving no treatment. The authors of the research recommended the flavonoids can guard the interior of the kidney from the oxidative risk that could start the stone formation.

Another research with the rodent and laboratory properties stated that the effects of catechin on calcium oxalate-mediated kidney risk. Catechin protected the kidney cells on the oxidative stress caused by calcium oxalate in the laboratory setting. Catechin seems to guard rats on the oxidative effects of calcium oxalate in the animal part of the research (Zhai 2013).

Quercetin

Quercetin has been examined in preclinical and laboratory models because of its protective effect on the generation of kidney stone. A certain animal trial differentiated the connected molecule hyperoside and a concoction of quercetin to potassium citrate for curing oxalate stones. The quercetin-hyperoside concoction reduced the levels of crystal withdrawals in kidney tissue, unlike with antioxidant enzyme and potassium citrate activity was raised (Zhu 2014). Quercetin protected the oxalate-induced harm in both settings and guard the calcium oxalate crystal generation in rat kidney in another research with lab and animal components (Park 2008).

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